Association Study of Sequence Variants in Voltage-gated Ca2+ Channel Subunit Alpha-1C and Autism Spectrum Disorders.
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: ) encodes an alpha-1 subunit of a voltage-dependent calcium channel. Genetic variants within this gene have been associated with psychiatric disorders including Autism Spectrum Disorders (ASD). Our aim was to determine whether the SNPs rs1006737, rs4765905, and rs4765913 were associated with ASD in an Iranian population. METHODS: and the risk of ASD in a population of 529 Iranian ASD patients and 480 age, gender, and ethnicity-matched healthy subjects. RESULTS: None of these SNPs were associated with ASD risk in the assessed population. Although previous studies have shown an association between these polymorphisms and psychiatric disorders and an association between rs4765905 and ASD, we did not replicate those results in our study. CONCLUSION: variants are not involved in the pathogenesis of ASD in the Iranian population.
Source: Europe PMC (PubMed Central)
Authors: Arezou Sayad, Soudeh Ghafouri-Fard, Rezvan Noroozi, Mir Davood Omrani, Maziar Ganji, Romina Dastmalchi, Mark Glassy, Mohammad Taheri
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2942774191