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Atomic Force Microscopy Demonstrates that Candida glabrata Uses Three Epa Proteins To Mediate Adhesion to Abiotic Surfaces

Year: 2019

Type: article

Abstract: to abiotic surfaces through molecular interactions that are poorly understood. Here, we study the forces engaged in Epa-dependent adhesion using single-cell techniques. Fungal adhesion to hydrophilic and hydrophobic substrates involves mainly three Epa proteins, suggesting a broad role for the Epa adhesins in mediating adherence. These proteins might represent a potential target for the development of innovative antifungal drugs.

Source: mSphere

DOI: 10.1128/msphere.00277-19

Authors: Claire Valotteau, Valeria Prystopiuk, Brendan P. Cormack, Yves F. Dufrêne

Institutions: UCLouvain, Johns Hopkins University, Johns Hopkins Medicine, Walloon Excellence in Lifesciences and Biotechnology

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500