Особливості функціонального стану щитоподібної залози в дітей з ожирінням
Year: 2017
Type: article
Study design: Observational Study
Abstract: Objective — to study agerelated and sexrelated peculiarities of functional state of thyroid gland in children with obesity.Materials and methods. There was a complete examination of 212 children with obesity (including 124 boys and 88 girls) using standard criteria for diagnosis of thyropathies, by presence of which the patients were divided into following groups: those with autoimmune thyroiditis, those with diffuse nontoxic goiter and those with minimal changes of thyroid gland structure against the absence of characteristics of autoimmune thyroiditis. Patients were divided into three groups by age and sex (prepuberty, early puberty and puberty itself). Software packages «Statgraphics centurion XV» and «Microsoft Excel 2010» were used for statistical processing of results.Results and discussion. It was determined that a quarter of children with obesity display hyperthyrotropinemia, prevalence of which decreases with age and increase of sexual maturity rating. Minimal thyroid deficiency and subclinical hypothyroidism in children with obesity is the most prevalent at prepuberty and early puberty age (42.4 % at early puberty age and 45.3 % at prepuberty age, especially in boys aged 6–9 years (50 %). Specific gravity of minimal thyroid deficiency is higher in obese patients without symptoms of thyroid gland damage, than against the presence of thyropathies, which are more often concomitant with subclinical hypothyroidism.Conclusions. Formation of thyropathies in children with obesity is often concomitant with symptoms of minimal thyroid deficiency and subclinical hypothyroidism, prevalence of which has genderrelated characteristics, while pathological changes in thyroid hormone and TSH figures depend to a great degree on age and puberty stage.
Author: О. В. Шушляпіна
Language: Ukrainian
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2942821594