Work

A new approach to discovery of S100 protein heterodimers

Year: 2019

Type: article

Abstract: S100 proteins are a sub-family of EF-hand calcium binding proteins that form very similar, unique dimer structures. Although the possibility has been known for many years, no systematic study of the formation of S100 protein heterodimers has been reported. Shaw and coworkers demonstrate the application of a new approach that provides an in-depth evaluation of the distribution of S100 protein homo- and heterodimer and show that the prevalence of heterodimers may be much higher than previously anticipated.

Source: FEBS Journal

DOI: 10.1111/febs.14851

Authors: Velia Garcia, Walter J. Chazin

Institution: Vanderbilt University

Language: English

Topic: S100 Proteins and Annexins

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green