Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness
Year: 2019
Type: article
Abstract: Our study defines the allelic distribution of pfcrt , an important mediator of multidrug resistance in Plasmodium falciparum , in Africa and Asia. We leveraged whole-genome sequence analysis and gene editing to demonstrate how current drug combinations can select different allelic variants of this gene and shape region-specific parasite population structures. We document the ability of PfCRT mutations to modulate parasite susceptibility to current antimalarials in dissimilar, pfcrt allele-specific ways. This study underscores the importance of actively monitoring pfcrt genotypes to identify emerging patterns of multidrug resistance and help guide region-specific treatment options.
Source: mBio
Institution: Columbia University Irving Medical Center
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
Awards: Role of pfcrt in chloroquine resistance in P. falciparum, Medical Scientist Training Program, G5277289607, Dissecting the molecular basis of PfCRT-mediated antimalarial drug resistance, Columbia Integrated Training Program in Infectious Diseases Research, Defining the genetic basis of piperaquine resistance in P. falciparum to support malaria elimination, Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance, Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparum, Defining P. falciparum resistance to artemisinin-based combination therapies
OpenAlex ID: W2943327371