Year: 2019
Type: review
Abstract: Over the last decades, the fabrication of 3D tissues has become commonplace in tissue engineering and regenerative medicine. However, conventional 3D biofabrication techniques such as scaffolding, microengineering, and fiber and cell sheet engineering are limited in their capacity to fabricate complex tissue constructs with the required precision and controllability that is needed to replicate biologically relevant tissues. To this end, 3D bioprinting offers great versatility to fabricate biomimetic, volumetric tissues that are structurally and functionally relevant. It enables precise control of the composition, spatial distribution, and architecture of resulting constructs facilitating the recapitulation of the delicate shapes and structures of targeted organs and tissues. This Review systematically covers the history of bioprinting and the most recent advances in instrumentation and methods. It then focuses on the requirements for bioinks and cells to achieve optimal fabrication of biomimetic constructs. Next, emerging evolutions and future directions of bioprinting are discussed, such as freeform, high-resolution, multimaterial, and 4D bioprinting. Finally, the translational potential of bioprinting and bioprinted tissues of various categories are presented and the Review is concluded by exemplifying commercially available bioprinting platforms.
Source: Small
Institutions: Brigham and Women's Hospital, Harvard University, University of Twente, Donghua University, Tecnológico de Monterrey, Gebze Technical University, Sabancı Üniversitesi, Beihang University, Shanghai Jiao Tong University, Renji Hospital, Zhejiang University, University Medical Center Utrecht, University of Nebraska Medical Center
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Awards: Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer Therapy, G2079815460, Developing Hybrids of Cardiac Tissue and Biodegradable Electronics Towards Heart Implants with On-line Monitoring and Stimulating Functions, Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer Therapy, Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor Models, G8016631334
OpenAlex ID: W2943437279