Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children Treated with Cranial Radiation for Brain Tumours
Year: 2018
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: OBJECTIVES: Cranial radiation results in neuronal insult and cognitive impairment in brain tumour survivors (BTS). Metformin increases neurogenesis and improves memory in mice. We conducted a pilot double-blind randomized controlled crossover trial to examine the effects of metformin versus placebo on hippocampal and white matter (WM) volume, and cognitive processes in BTS. METHODS: Twenty four participants were randomly assigned to complete 12-week cycles of Metformin (A) and Placebo (B) in either an AB or BA sequence. Assessment at baseline and immediately following treatment included: (a) structural MRI to obtain hippocampal subfield and WM volume, and (b) cognitive testing. Linear mixed modelling was used to measure changes in outcome measures with respect to treatment, cycle, and carryover. FINDINGS: Treatment and carryover effects were observed, suggesting ongoing effects up to 22 weeks following treatment. CONCLUSION: Metformin may be effective for normalizing brain structure and cognitive processes in BTS.
Source: TSpace (University of Toronto)
Author: Ramy Ayoub
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2943597896