Year: 2019
Type: article
Abstract: Inflammatory bowel disease (IBD) is associated with immune dysregulation triggered by environmental factors, microbial dysbiosis, and genetical susceptibility. Regulatory T cells (Tregs) are critical in controlling intestinal immune homeostasis and Treg deficiencies trigger intestinal inflammation.1,2 Interleukin (IL)-2 is a key cytokine controlling differentiation, survival, and function of Tregs.3 In contrast to conventional T cells (Tcon), Tregs exhibit higher sensitivity to IL-2 due to constitutive expression of CD25, the high-affinity subunit of the IL-2 receptor.
Authors: Jeremy A. Goettel, Daniel Kotlarz, Rohini Emani, James B. Canavan, Liza Konnikova, David Illig, Sandra M. Frei, Michael Field, Matthew Kowalik, Kaiyue Peng, Jordan Gringauz, Vanessa Mitsialis, Sarah M. Wall, Amy Tsou, Alexandra E. Griffith, Ying Huang, Joshua R. Friedman, Jennifer E. Towne, Scott E. Plevy, Aisling O’Hara Hall, Scott B. Snapper
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,000
Funders: Leona M. and Harry B. Helmsley Charitable Trust, Crohn's and Colitis Foundation, IFM Therapeutics, Deutscher Akademischer Austauschdienst, Daimler und Benz Stiftung, International Pediatric Research Foundation, Allergan, Harvard Digestive Diseases Center, Harvard University, National Institute of Diabetes and Digestive and Kidney Diseases, Janssen Research and Development
OpenAlex ID: W2943868072