Analgesic, Antiedematous and Wound Healing Properties of AX/09 in the Treatment of Swelling and Poorly Healing Skin Defects in Rodents
Year: 2011
Type: article
Abstract: In the present paper the therapeutic effect of AX/09 preparation containing a mixture of terpene natural oils and AVILIN, a thick viscous liquid with anti-infl ammatory, antibacterial and tissue-regenerating properties is studied.The antinociceptive and antiedematous activities of AX/09 were investigated in the Randall-Selitto test and carrageenan-induced hind paw edema model in rats.The burn wound-healing properties of AX/09 in chemical and thermal burn models were studied in mice and rats, respectively.To determine the stage of the wound repair process a few methods were used.The wound surface area was measured planimetrically.The development of the granulation tissue and its transformation into young skin, the presence of infi ltrates and exudates within the damaged skin were measured micrometrically by skinfold thickness.Planimetric observations of the wound surface area and micrometric measurements of effusions and infi ltrates showed that the healing process of the chemically-induced burn wound was more balanced and much faster after treatment with AX/ 09.In this model, in animals treated with AX/09 the whole granulation tissue was transformed into young epidermis after 17 days, while in the group treated with AVILIN and in the control group a similar effect was observed after 20 and 23 days, respectively.Much less convincing results were observed in animals treated with AX/09 in thermally-induced burn models.In animals treated with AX/09 complete wound closure by the newly formed epidermis was observed after 21 days.In the group treated with vehiculum a similar effect was observed after 22 days and in the control group after 24 days.There were no toxic skin reactions after the fi rst contact with the skin, as well as after multiple applications of AX/09.AX/09 did not cause a delayed-type allergic reaction.The effi cacy of AX/09 and its infl uence on the burn wound healing process, especially in chemical models, seems to be of special value for the clinical, especially dermatological, practice.
Language: English
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2943958291