Association Between Progression of Retinopathy and Concurrent Progression of Kidney Disease
Year: 2019
Type: article
Abstract: Importance: Associations between retinopathy and kidney disease have been previously described. The association between the progression of retinopathy and concurrent progression of chronic kidney disease is unknown. Objective: To assess the association between progression of retinopathy and concurrent progression of chronic kidney disease (CKD) among persons with CKD enrolled in a prospective cohort study. Design, Setting, and Participants: A total of 1936 patients with chronic kidney disease enrolled in the multicenter, prospective Chronic Renal Insufficiency Cohort (CRIC) Study were invited to have 2 nonmydriatic fundus photography sessions separated by a mean (SD) of 3.5 (0.5) years. The study was conducted from May 12, 2006, to June 29, 2011. Data analysis was performed from March 16, 2016, to November 17, 2017. Main Outcomes and Measures: Fundus photographs obtained at baseline and then at a follow-up at 3.5 years were reviewed by masked graders for presence and severity of retinopathy, and vessel calibers were assessed using standard protocols. The associations of the changes in retinal features with progression of CKD (50% estimated glomerular filtration rate [eGFR] loss or incident end-stage renal disease, and differences in eGFR slope in the same time period) were assessed with univariable and multivariable logistic regression models. Results: Among 1583 CRIC participants who had baseline fundus photography, had additional follow-up in CRIC, and were at risk for retinopathy progression, 1025 patients (64.8%) had follow-up photography. The odds ratio (OR) for CKD progression associated with worsening of retinopathy in comparison with participants with stable retinopathy was 2.24 (95% CI, 1.28-3.91; P = .005) in univariable analysis among participants with baseline and follow-up photography. In the multivariable analysis, the OR was 1.62 (95% CI, 0.77-3.39; P = .20). The multiple imputation analysis provided similar results. Conclusions and Relevance: Progression of retinopathy appears to be associated with progression of CKD on univariable analysis but not on multivariable analysis suggesting that similar risk factors may be affecting the progression of both retinal and chronic kidney disease.
Source: JAMA Ophthalmology
Authors: Juan E. Grunwald, Maxwell Pistilli, Gui-Shuang Ying, Ebenezer Daniel, Maureen Maguire, Dawei Xie, Jason Roy, Revell Whittock-Martin, Candace Parker Ostroff, Joan C. Lo, Raymond R. Townsend, Crystal A. Gadegbeku, James P. Lash, Jeffrey C. Fink, Mahboob Rahman, Harold I. Feldman, John W. Kusek, for the Chronic Renal Insufficiency Cohort Study Investigators
Institutions: University of Pennsylvania, Kaiser Permanente Northern California, Temple University, University of Illinois Chicago, University of Maryland, Baltimore, University Hospitals of Cleveland, University Hospitals Cleveland Medical Center, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Clinical and Translational Science Institute, Hispanic Chronic Renal Insufficiency Cohort(CRIC) Study, Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study, GENERAL CLINICAL RESEARCH CENTER, Center for Clinical and Translational Science, Clinical and Translational Science Award, Clinical and Translational Science Collaborative of Cleveland, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases, A pilot trial of an intervention to support initial type 2 diabetes selfmanagement among younger adults with children., Prospective renal insufficiency cohort evaluation: PRICE, Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center, Continuation of the Chronic Renal Insufficiency Cohort (CRIC), Continuation of the University of Illinois Chicago CRIC Clinical Center, P30 Core Grant For Vision Research, Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center, Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study, Chronic Renal Insufficiency Cohort Limited competition continuation, Chronic Renal Insufficiency Cohort (CRIC) Study
OpenAlex ID: W2944073789