Year: 2019
Type: review
Abstract: This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to enable direct liquid sample analysis, coupling to HPLC for real-time AMS analysis, and combined molecular mass spectrometry and AMS for analyte identification and quantitation. Laser-based alternatives, such as cavity ring down spectrometry, are emerging to enable lower cost, higher throughput measurements of biological samples. Applications covered include radiocarbon dating, use of environmental atomic bomb pulse radiocarbon content for cell and protein age determination and turnover studies, and carbon source identification. Low dose toxicology applications reviewed include studies of naphthalene-DNA adduct formation, benzo[a]pyrene pharmacokinetics in humans, and triclocarban exposure and risk assessment. Cancer-related studies covered include the use of radiocarbon-labeled cells for better defining mechanisms of metastasis and the use of drug-DNA adducts as predictive biomarkers of response to chemotherapy.
Source: Toxics
Language: English
Subfield: Paleontology
Field: Earth and Planetary Sciences
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,013
Funders: U.S. Department of Energy, American Cancer Society, U.S. Department of Veterans Affairs, National Institutes of Health, University of California, Davis, National Cancer Institute, National Institute of General Medical Sciences, Laboratory Directed Research and Development, Comprehensive Cancer Center, University of California, Davis, Lawrence Livermore National Laboratory
Awards: G112505928, G1210402667, G1356433355, G14554683, G1716777315, G2075359013, G2145270357, G2684230466, G3511754856, G358449778, G3669113783, G4261132398, G4744444288, G5300104790, G5630301777, G632693473, G6838344219, G7790607044, G7938659809, Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS), Targeted-and timed-releasing nanotherapeutics against leukemia stem cells, G895790057, G9000015183, UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development Program, Cancer Center Support Grant P30, G991281326
OpenAlex ID: W2944252253