Work

Acute drivers of neuroinflammation in traumatic brain injury

Year: 2019

Type: article

Abstract: Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology. Immune cells respond to acute signals from damaged cells, initiate neuroinflammation, and drive the pathological consequences over time. Importantly, the mechanism(s) of injury, the location of the immune cells within the brain, and the animal species all contribute to immune cell behavior following traumatic brain injury. Understanding the signals that initiate neuroinflammation and the context in which they appear may be critical for understanding immune cell contributions to pathology and regeneration. Within this paper, we review a number of factors that could affect immune cell behavior acutely following traumatic brain injury.

Source: Neural Regeneration Research

DOI: 10.4103/1673-5374.255958

Authors: Kathryn L. Wofford, David J. Loane, D. Kacy Cullen

Institutions: Philadelphia VA Medical Center, Drexel University, University of Pennsylvania, University of Maryland, Baltimore, Trinity College Dublin

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500