Effect of new xanthone derivatives on the level of endogenous nitric oxide in some tissue homogenates in rats
Year: 2011
Type: article
Abstract: Nitric oxide (NO) is synthesized from L-arginine by NO synthase (NOS) in endothelial cells.It has been found that the levels of endogenous inhibitors of NOS, which inhibit NO synthesis, are signifi cantly increased in animals and patients with atherosclerosis and hypertension.Free NO is known to be involved in the central and peripheral regulation of cardiovascular function.In our previous research we examined a series of new aminoalcanolic derivatives of xanthone, which had high antiarrhythmic and/or hypotensive activity and high affi nity for α/β 1 -adrenoceptors.We suppose that hypotensive activity could be connected with α/β 1 -adrenoceptor blocking properties.The aim of the present study was to examine the possible involvement of other mechanisms in the observed hypotensive properties so we assessed the involvement of the most active xanthone derivatives in the NO pathway.We measured the infl uence of new xanthone derivatives on the level of endogenous nitric oxide in some tissue homogenates using Griess's method.However, none of the tested compounds signifi cantly increased the NO level in the heart, liver, kidney or brain tissues, as compared with the control.The results indicate that the mechanism of the hypotensive action of the examined new xanthone derivatives is not connected with the release of endogenous NO.
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2944348877