Arthritis, Sleep Health, and Systemic Inflammation in Older Men
Year: 2019
Type: article
Abstract: OBJECTIVE: To examine the associations of prevalent arthritis with systemic inflammation in older men and to test whether sleep health mediates the associations. METHODS: Cross-sectional data came from 2,562 community-dwelling older men (all were age 65 years or older; mean age 76 years) in the Osteoporotic Fractures in Men Study who participated in a sleep ancillary study in 2003-2005. Participants were classified as having osteoarthritis (OA) (24%) or rheumatoid arthritis (RA) (0.7%) based on self-reported diagnoses and medication use. We constructed a composite score of multidimensional sleep health (i.e., perceived sleep quality, sleepiness, frequency of daytime napping, wake after sleep onset, and sleep duration) measured by both self-report and actigraphy. We also created binary indicators of elevated inflammation using C-reactive protein (CRP) (>3 mg/liter) and interleukin-6 (IL-6) (>1.08 pg/ml) levels. Analyses controlled for age, diagnosed sleep disorders, body mass index, smoking status, relevant medication use, and comorbidities. RESULTS: Older men with OA did not have higher risk of elevated CRP or IL-6 levels. However, indirect associations of OA through sleep health were found. OA was associated with poorer sleep health, which was further associated with 16% higher odds of elevated CRP (P < 0.001) and 12% higher odds of elevated IL-6 (P < 0.01) levels after controlling for OA. Older men with RA had higher odds of elevated CRP and IL-6 levels, but the associations were not mediated by sleep health. CONCLUSION: Findings suggest that promoting sleep health may help reduce the risk of systemic inflammation in older men with OA.
Source: Arthritis Care & Research
DOI: 10.1002/acr.23923
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Outcomes of Sleep Disorders in Older Men-Minneapolis, Osteoporotic Fractures in Men (MrOS) - Minneapolis, G1825185440, Oregon Clinical and Translational Research Institute, Osteoporatic Fractures in Men (MrOS), Outcomes of Sleep Disorders in Older Men- Reading Center, Long-term fracture risk in older men: the MrOS study, Osteoporotic Fractures in Men (Mr. Os) Palo Alto, G4040455558, Osteoporotic Fractures in Men (MrOS) - Administrative Center, G5840732910, Non-pharmacological improvement of sleep structure in older people, Outcomes of Sleep Disorders in Older Men-Portland, Osteoporotic Fractures in Men (Mr.OS), Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating Center, G6829069558, Osteoporotic Fractures in Men (MrOS) - Portland, Outcomes of Sleep Disorders in Older Men-Palo Alto, Outcomes of Sleep Disorders in Older Men, Osteoporotic Fractures in Men_MrOS Renewal_Birmingham, Outcomes of Sleep Disorders in Older Men, Building Interdisciplinary Research Careers in Women's Health at UC Davis, Outcomes of Sleep Disorders in Older Men-Birmingham, Outcomes of Sleep Disorders in Older Men - Pittsburgh, The Epidemiology and Genetics of Hip OA in Elderly Men, Building Interdisciplinary Research Careers in Women's Health at UC Davis
OpenAlex ID: W2944406946