Comparative Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Response to a Physical Activity Intervention in Older Adults: Results From the Lifestyle Interventions and Independence for Elders Study
Year: 2019
Type: article
Abstract: BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) may protect against aging-related decline. This study directly compared ACEis and ARBs on associations with risk of mobility disability in older adults when combined with a physical activity intervention. METHODS: This was a secondary analysis of the Lifestyle Interventions and Independence for Elders (LIFE) trial. Participants aged 70-89 years were randomized to a physical activity or health education intervention. Outcomes included incident and persistent major mobility disability, injurious falls, short physical performance battery, and gait speed. For this analysis, only participants who reported ACEi or ARB use at baseline were included. Baseline differences between ACEi and ARB groups were adjusted for using inverse probability of treatment weights. Weighted Cox proportional hazard models and analysis of covariance models were used to evaluate the independent effects of medications and interaction effects with the intervention on each outcome. RESULTS: Of 1,635 participants in the Lifestyle Interventions and Independence for Elders study, 796 used either an ACEi (496, 62.3%) or ARB (300, 37.7%). Compared with ACEi users, ARB users had 28% lower risk (hazard ratio [HR] = 0.72 [0.60-0.85]) of incident major mobility disability and 35% (HR = 0.65 [0.52-0.82]) lower risk of persistent major mobility disability whereas no interaction between medication use and intervention was observed. Risk of injurious falls and changes in short physical performance battery or gait speed were not different between ARB and ACEi users. CONCLUSIONS: These results suggest that ARBs may protect from major mobility disability by other mechanisms than improving physical performance.
Institutions: University of Florida Health, University of Florida, University of Pittsburgh, Wake Forest University Health Sciences, Wake Forest University, Yale University, University of South Carolina, Tufts University, Jean Mayer Human Nutrition Research Center on Aging, University of Alabama at Birmingham, UAB Medicine
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Yale University, Wake Forest University, University of Florida, University of Pittsburgh, Tufts University, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1029652654, G1044130170, G1153142239, G1501842456, G1625562486, Improving Outcome Measurement for Medical Rehabilitaiton Clinical Trials, G2027230101, Advancing Personalized Hypertension Care through Big Data Science, Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1, Stanford Center for Clinical & Translational Education and Research (Spectrum), G3306042508, G3420384484, G3522550915, G3570311933, G4245087604, G4365909528, G459450967, G5659566681, G5941384172, G640327682, G644155597, G6580905561, G6651842563, G669199263, G6855373311, G6881567127, G7064730017, G76888958, G7986419726, Yale University Clinical and Translational Science Award Program, G9000021181, G9000039460, G9000060350, G9000151466, G9000156850, G9000171061, G9000175663, G9000208770, G9000326834, University of Florida Older Americans Independence Center (OAIC)
OpenAlex ID: W2944512348