Selective inhibition of HDAC6 induces DNA damage and apoptosis and sensitizes colon cancer cells to anticancer agents
Year: 2014
Type: dissertation
Abstract: pan-HDAC inhibitor SAHA in colon cancer cells.A452 in combination with irinotecan, capecitabine or SAHA is more potent than either drug alone in the apoptotic pathway, as evidenced by an increase in PARP cleavage.Furthermore, A452 enhances DNA damage induced by irinotecan, capecitabine or SAHA as indicated by increased accumulation of H2AX and activation of the checkpoint kinase Chk2.However, A452 does not increase cisplatin-induced cytotoxicity in HCT116 and HT29 cells.Therefore, these findings indicate that A452 is a specific HDAC6 inhibitor and point mechanism by which HDAC6-selective inhibition can enhance the efficacy of certain anti-cancer agents in colon cancer cells.
Author: 신동희
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2944515454