Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: Carboxymethyl-lysine is an advanced glycation end product that is detectable in the serum. Higher carboxymethyl-lysine levels have been associated with increased risk of coronary heart disease, stroke and cardiovascular mortality. We determined whether high carboxymethyl-lysine levels are also associated with the risk of peripheral artery disease in Cardiovascular Health Study participants who were all aged 65 years and older at baseline. Multivariate Cox proportional hazards models were used to determine the association of baseline carboxymethyl-lysine levels with incident peripheral artery disease in 3267 individuals followed for a median length of 10.0 years. A total of 157 cases of incident peripheral artery disease occurred during follow-up. No significant relationship between carboxymethyl-lysine and risk of peripheral artery disease was found (hazard ratio per standard deviation increment = 1.03; 95% confidence interval = 0.87, 1.23).
Institutions: University of Southern California, University of Washington, Kaiser Permanente, Brigham and Women's Hospital, Harvard University, University of California Davis Medical Center, University of California San Diego, San Francisco VA Medical Center, University of California, San Francisco, San Francisco VA Health Care System, University of Vermont, University of Pittsburgh, New York Academy of Medicine, Beth Israel Deaconess Medical Center
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: green
Awards: G1220223050, G124305487, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, G2194386449, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, Determinants and Cardiovascular Consequences of Diabetes in Older Adults, G2391884931, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G2999014547, G3045517347, G3220743633, G3256118428, CHS research resources for the cardiovascular health of older adults, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G4617276643, G5479317095, G581887176, CHARGE consortium: omics discovery for CVD and aging phenotypes, CHS Events Follow-up Study, G6226795708, CHS-Transition Phase, G7176672723, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G8402048158
OpenAlex ID: W2944541312