Work

Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance

Year: 2019

Type: review

Abstract: folate biosynthesis pathway and must obtain folate from commensal microbiota or the environment using proton-coupled folate transporters. The essentiality and dichotomy between mammalian and bacterial folate biosynthesis and utilization pathways make it an ideal drug target for the development of antimicrobial agents and cancer chemotherapeutics. In this minireview, we discuss general aspects of folate biosynthesis and the underlying mechanisms that govern susceptibility and resistance of organisms to antifolate drugs.

Source: MedChemComm

DOI: 10.1039/c9md00078j

Authors: Shannon Lynn Kordus, Anthony David Baughn

Institution: University of Minnesota

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Minnesota, National Institute of Allergy and Infectious Diseases