Work

Central aspects of systemic oestradiol negative‐ and positive‐feedback on the reproductive neuroendocrine system

Year: 2019

Type: review

Abstract: The central nervous system regulates fertility via the release of gonadotrophin-releasing hormone (GnRH). This control revolves around the hypothalamic-pituitary-gonadal axis, which operates under traditional homeostatic feedback by sex steroids from the gonads in males and most of the time in females. An exception is the late follicular phase in females, when homeostatic feedback is suspended and a positive-feedback response to oestradiol initiates the preovulatory surges of GnRH and luteinising hormone. Here, we briefly review the history of how mechanisms underlying central control of ovulation by circulating steroids have been studied, discuss the relative merit of different model systems and integrate some of the more recent findings in this area into an overall picture of how this phenomenon occurs.

Source: Journal of Neuroendocrinology

DOI: 10.1111/jne.12724

Authors: Suzanne M. Moenter, Marina A. Silveira, Luhong Wang, Caroline Adams

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Hypothalamic control of reproductive hormones

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze