Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke
Year: 2019
Type: article
Abstract: Significance Stroke is one of the most prevalent types of acute brain injury, and rehabilitation poses globally a significant personal as well as socioeconomic burden. We here demonstrate a potent mitigation of stroke-induced brain damage by blocking adrenergic receptors. Stroke induces cortical spreading depolarizations which repeatedly increases extracellular potassium. We show that adrenergic receptor antagonism promotes the normalization of extracellular medium following stroke. From a translational standpoint, this approach may offer an affordable approach to current treatments such as tissue plasminogen activator administration and mechanical thrombectomy.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Defense, Human Frontier Science Program, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, University of Utah, Keio University, Ministry of Education, Culture, Sports, Science and Technology, Lundbeckfonden, Novo Nordisk, Novo Nordisk Fonden, H. Lundbeck A/S, Japan Society for the Promotion of Science, RIKEN, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Awards: G120759439, G1453837003, G1584462817, G1629453761, G1976807682, G2057757982, G2299739175, G2564808885, Mitochondrial G Protein signaling in astrocytes: a new player in the tripartite synapse, Development of new therapy for neuromyelitis optica using its animal models and anti-AQP4 antibodies., Physiology relevance of cerebral lymphatic flow and the mechanism of higher brain dysfunction due to its breakdown, G3766330258, Cortical circuit plasticity supported by glia, Development of a new therapy for brain edema: study for regulation of AQP4 as a molecular target, G4392196545, G4449473775, G4680301762, G4817715770, G5015935183, G5721720623, G583086298, G664524796, The mechanisms of extracellular ion homeostasis by brain fluid dynamics, G8800611140, Elucidation of pathomechanism of Alzheimer's disease focusing on AQP4 function and lymphatic drainage system in the brain.
OpenAlex ID: W2945065111