Year: 2019
Type: review
Abstract: The ability of circulating CD4+ T cells to retain memories of previous antigenic encounters is a cardinal feature of the adaptive immune system. Over the past two decades, since the first description of central and effector memory T cells, many studies have examined molecular mechanisms controlling CD8+ T‐cell memory, with comparatively less research into CD4+ T‐cell memory. Here, we review a number of seminal studies showing that circulating memory CD4+ T cells develop directly from effector cells; and in so doing, preserve features of their effector precursors. We examine mechanisms controlling the development and phenotypes of memory CD4+ T cells, and provide an updated model that accommodates both the central and effector memory paradigm and the diverse T helper cell classification system.
Source: Immunology and Cell Biology
DOI: 10.1111/imcb.12272
Authors: Megan SF Soon, Jessica A Engel, Hyun J Lee, Ashraful Haque
Institution: QIMR Berghofer Medical Research Institute
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Award: G3025122566
OpenAlex ID: W2945071464