Year: 2019
Type: preprint
Abstract: Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state. However, tumors may induce NK cell conversion into ILC1-like cells that are limited to the tumor microenvironment and whether this conversion occurs beyond this environment remains unknown. Here we describe Toxoplasma gondii infection converts NK cells into cells resembling steady-state ILC1s that are heterogeneous and distinct from both steady-state NK cells and ILC1s in uninfected mice. Most toxoplasma-induced ILC1s were Eomes-dependent, indicating that NK cells can give rise to Eomes − Tbet-dependent ILC1-like cells that circulate widely and persist independent of ongoing infection. Moreover, these changes appear permanent, as supported by epigenetic analyses. Thus, these studies markedly expand current concepts of NK cells, ILCs, and their potential conversion.
DOI: 10.1101/642017
Authors: Eugene Park, Swapneel J. Patel, Qiuling Wang, Prabhakar S. Andhey, Konstantin Zaitsev, Sofia I. Porter, Maxwell L. Hershey, Michael D. Bern, Beatrice Plougastel-Douglas, Patrick L. Collins, Marco Colonna, Kenneth M. Murphy, Eugene M. Oltz, Maxim N. Artyomov, L. David Sibley, Wayne M. Yokoyama
Language: English
Topic: IL-33, ST2, and ILC Pathways
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1114310655, G12431752, G1485266116, G1860241766, G2052854178, G2118016120, G245842400, G299873027, G4241677154, G5392049660, SEQUENCE-SPECIFIC CHROMATIN MODIFIERS; NOVEL PROTEIN THERAPEUTICS FOR B CELL LYMPHOMA, G7647900390, G8242737674, G8405709672, G9000005743, G9000115080, G9000189848, G9000216324, G9000319192, Cancer Center Support Grant
OpenAlex ID: W2945103147