Year: 2019
Type: editorial
Abstract: Colorectal adenocarcinoma is one of the most common cancer diagnoses worldwide and a leading cause of cancer mortality in the United States. Through decades of research there have been multiple routes of colorectal cancer formation identified. The molecular drivers of progression in these pathways are varied and range from genomic, epigenomic, and environmental. The traditional or chromosomal instability pathway, which generally arises from progression of colon adenomas, is thought to stem from loss of APC followed by activating mutations in KRAS and then alterations in the tumor-suppressor gene TP53, leading to chromosomal instability.
Author: Matthew D. Stachler
Institution: University of California, San Francisco
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,000
OpenAlex ID: W2945104981