Work

At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1

Year: 2019

Type: editorial

Abstract: Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce cervical carcinogenesis. We found that synergism between hyperactivated YAP1 and high-risk HPV is a key driver of cervical cancer initiation and progression.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2019.1612677

Authors: Cheng Wang, John S Davis

Institutions: Harvard University, Massachusetts General Hospital, Omaha VA Medical Center, University of Nebraska Medical Center

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590