Work

Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure–activity relationships

Year: 2015

Type: article

Abstract: The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle (Silybum marianum) extract provided an entré into the isolation of two related analogs that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin A and isosilybin B, respectively, afforded a preliminary analysis of structure-activity relationships toward prostate cancer growth, survival, and apoptotic endpoints.

Source: NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)

Authors: Tyler N. Graf, Nicholas H. Oberlies

Language: English

Topic: Silymarin and Mushroom Poisoning

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Golden LEAF Foundation, National Institutes of Health, National Cancer Institute

Award: G8797294987

OpenAlex ID: W2945338794