Work

DNA methylation modifications induced by hexavalent chromium

Year: 2019

Type: article

Abstract: Hexavalent chromium [Cr (VI)] contributes a significant health risk and causes a number of chronic diseases and cancers. While the genotoxic and carcinogenic effects of hexavalent chromium exposure are explicit and better-characterized, the exact mechanism underlying the carcinogenic process of Cr (VI) is still a matter of debate. In recent years, studies have shown that epigenetic modifications, especially DNA methylation, may play a significant role in Cr (VI)-induced carcinogenesis. The aim of this review is to summarize our understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.

Source: Journal of Environmental Science and Health Part C

DOI: 10.1080/10590501.2019.1592640

Authors: Xinnian Guo, Lingfang Feng, Bernardo Lemos, Jianlin Lou

Institutions: Zhejiang Academy of Medical Sciences, Harvard University

Language: English

Topic: Chromium effects and bioremediation

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, National Institute of Environmental Health Sciences