Work

Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses’ Health Study II

Year: 2019

Type: article

Study design: Observational Study

Abstract: BACKGROUND: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. METHODS: We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12-22 years) in 1997 and underwent lower bowel endoscopy (1998-2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. RESULTS: = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66-0.88; advanced adenoma: OR 0.61; 95% CI 0.45-0.82) compared to women with low physical activity during both stages of life. CONCLUSIONS: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.

Source: British Journal of Cancer

DOI: 10.1038/s41416-019-0454-1

Authors: Leandro Fórnias Machado de Rezende, Dong Hoon Lee, NaNa Keum, Katharina Nimptsch, Mingyang Song, I-Min Lee, José Eluf-Neto, Shuji Ogino, Charles Fuchs, Jeffrey Meyerhardt, Andrew T. Chan, Walter Willett, Edward Giovannucci, Kana Wu

Institutions: Harvard University, Universidade de São Paulo, Dongguk University, Max Delbrück Center, Massachusetts General Hospital, Brigham and Women's Hospital, Broad Institute, Yale Cancer Center, Yale University, Smilow Cancer Hospital, Dana-Farber Cancer Institute

Language: English

Topic: Colorectal Cancer Screening and Detection

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,300

Funders: American Cancer Society, American Institute for Cancer Research, Brigham and Women's Hospital, National Research Foundation, Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Dongguk University, National Research Foundation of Korea, National Institutes of Health, National Cancer Institute

Awards: G1036762147, G1051322630, Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1571532066, G183528732, G2010974632, G2789075706, Accelerating Transdisciplinary Epidemiology of Colorectal Cancer, Early life risk factors and risk of colorectal neoplasia, G3572101131, Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer Prevention, G3754462075, Integrating diet and tissue whole exome sequencing data to study processed meat and colorectal cancer, G4776526250, G5258272776, Life Course Cancer Epidemiology Cohort in Women, Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer Prevention, G605683873, G6137961998, G6200764915, Integrating diet, lifestyle and tumor tissue molecular subtyping to study the role of adolescent calcium intake on the risk of early onset colorectal neoplasia, G766275831, G7664999749, G8077455884, G8419718119, G8427443994, G9000031345, G9000058679, G9000131360, G921510112

OpenAlex ID: W2945736862

FWCI: 1.567

Cites: 43

Cited by: 27

Related to: 10