Year: 2019
Type: article
Abstract: Hyperpolarisation methods that premagnetise agents such as pyruvate are currently receiving significant attention because they produce sensitivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonance. Here, we communicate how signal amplification by reversible exchange (SABRE) can provide strong 13C pyruvate signal enhancements in seconds through the formation of the novel polarisation transfer catalyst [Ir(H)2(η2‐pyruvate)(DMSO)(IMes)]. By harnessing SABRE, strong signals for [1‐13C]‐ and [2‐13C]pyruvate in addition to a long‐lived singlet state in the [1,2‐13C2] form are readily created; the latter can be observed five minutes after the initial hyperpolarisation step. We also demonstrate how this development may help with future studies of chemical reactivity.
Institutions: University of York, Indian Institute of Science Bangalore
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
Awards: G2045251633, A National Centre for Translational Hyperpolarised Magnetic Resonance, G3467438248, Centre for Hyperpolarisation in MRI., G6412891576, Hyperpolarisation using SABRE as a new tool for imaging., G7510719559, A paradigm shift in low-field NMR spectroscopy for industrial process monitoring, control, and optimisation
OpenAlex ID: W2945828176