Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project
Year: 2019
Type: article
Abstract: Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measured using baseline body mass index (BMI), waist circumference, hip circumference, waist-to-hip, and waist-to-height ratios. HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models adjusted for sex, education, race, smoking, and alcohol consumption with age as the time metric and the baseline hazard stratified by study. During 37,883,648 person-years of follow-up, 1,343 GBC cases, 1,194 EHBDC cases, 784 IHBDC cases, and 623 AVC cases occurred. For each 5 kg/m2 increase in BMI, there were risk increases for GBC (HR = 1.27; 95% CI, 1.19–1.36), IHBDC (HR = 1.32; 95% CI, 1.21–1.45), and EHBDC (HR = 1.13; 95% CI, 1.03–1.23), but not AVC (HR = 0.99; 95% CI, 0.88–1.11). Increasing waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio were associated with GBC and IHBDC but not EHBDC or AVC. These results indicate that adult adiposity is associated with an increased risk of biliary tract cancer, particularly GBC and IHBDC. Moreover, they provide evidence for recommending weight maintenance programs to reduce the risk of developing these cancers. Significance: These findings identify a correlation between adiposity and biliary tract cancers, indicating that weight management programs may help minimize the risk of these diseases.
Source: Cancer Research
Authors: Sarah S. Jackson, Alison L. Van Dyke, Bin Zhu, Ruth M. Pfeiffer, Jessica L. Petrick, Hans-Olov Adami, Demetrius Albanes, Gabriella Andreotti, Laura E. Beane Freeman, Amy Berrington de González, Julie E. Buring, Andrew T. Chan, Yu Chen, Gary E. Fraser, Neal D. Freedman, Yu-Tang Gao, Susan M. Gapstur, J. Michael Gaziano, Graham G. Giles, Eric J. Grant, Francine Grodstein, Patricia Hartge, Mazda Jenab, Cari M. Kitahara, Synnove F. Knutsen, Woon-Puay Koh, Susanna C. Larsson, I-Min Lee, Linda M. Liao, Juhua Luo, Emma E. McGee, Roger L. Milne, Kristine R. Monroe, Marian L. Neuhouser, Katie M. O’Brien, Ulrike Peters, Jenny N. Poynter, Mark P. Purdue, Kim Robien, Dale P. Sandler, Norie Sawada, Catherine Schairer, Howard D. Sesso, Tracey G. Simon, Rashmi Sinha, Rachael Z. Stolzenberg-Solomon, Shoichiro Tsugane, Renwei Wang, Elisabete Weiderpass, Stephanie J. Weinstein, Emily White, Alicja Wolk, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Xuehong Zhang, Katherine A. McGlynn, Peter T. Campbell, Jill Koshiol
Institutions: National Cancer Institute, Division of Cancer Epidemiology and Genetics, University of Oslo, Karolinska Institutet, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University, Loma Linda University, Shanghai Cancer Institute, American Cancer Society, VA Boston Healthcare System, The University of Melbourne, Cancer Council Victoria, Radiation Effects Research Foundation, Centre international de recherche sur le cancer, National University of Singapore, Duke-NUS Medical School, Indiana University Bloomington, Indiana University, University of Southern California, Fred Hutch Cancer Center, National Institute of Environmental Health Sciences, University of Washington, University of Minnesota, George Washington University, National Cancer Centre Japan, University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Energy, World Health Organization, Wisconsin Historical Society, Wellcome Trust, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, Svenska Forskningsrådet Formas, National Institutes of Health, National Health and Medical Research Council, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Environmental Health Sciences, Niilo Helanderin Säätiö
Awards: TO INITIATE A NEW COOPERATIVE AGREEMENT WITH THE NATIONAL ACADEMY OF SCIENCE(NAS). NAS WILL SUPPORT THE LONG-TERM FOLLOW-UP OF THE HEALTH OF ATOMIC B, G1168185457, G1322431389, G1327305488, G134391464, Genetic And Environmental Risk Factors For Breast Cancer, G1644962498, G1734361364, G179365274, G1828895303, G1851278524, Plant-based diets and risk of cancer, G2099427675, G2145550945, G2214254730, G229684361, Health 2020, THE SINGAPORE COHORT STUDY OF DIET AND CANCER, G3062349281, G3086620026, G335053239, G3426488059, G3643850837, Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention, DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI, The NYU Women's Health Study, Dietary and Hormonal Determinants of Cancer in Women, G4282019567, G4450071017, G4582778782, G4751015949, G523675941, Physicians' Health Study II: Prevention Trial of Vitamins, G563478482, G5684079324, The Women's Health Study: Addition of New Data to Maximize its Research Impact, G5950317316, G6116049394, G6265217249, G6374948078, TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'S, PLATYPUSES, Epidemiology of Chronic Disease, Health Interventions and DNA Studies, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, G7026229329, G718805128, Prospective Studies of Diet and Cancer in Men and Women, G7332203415, Cancer epidemiology cohorts in Shanghai and Singapore , G771033555, G777640777, Women's Health Study: Continued Follow-up, Cancer Epidemiology Cohort in Male Health Professionals, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study, G846108443, G8554986239, G8606882599, G8615000715, PRACTICAL Australia, G9000000306, G9000061520, G9000160301, G92967239
OpenAlex ID: W2945858777