Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG Growth Study
Year: 2019
Type: article
Study design: Observational Study
Abstract: PURPOSE: The aim of this registry study was to analyze the long-term safety and effectiveness of recombinant human growth hormone (rhGH) in South Korean pediatric patients (≥2 years of age) with growth hormone deficiency GHD) of idiopathic or organic etiology, idiopathic short stature, Turner syndrome, small for gestational age and chronic renal failure. METHODS: The study patients were followed-up till two years after the epiphyseal closure, with visits scheduled every six months. The outcome measures included the incidence of adverse events (AEs, in particular, neoplasia, glucose intolerance and hypothyroidism), as well as height standard deviation score (Ht SDS) and annual height velocity. The results of the interim analysis of a 5-year accumulated data for 2,024 patients (7,342 patient-years, PY) are presented. RESULTS: A total of 14 neoplasms were diagnosed (191/100,000 PY); 7 out of 9 malignancies were recurrent craniopharyngioma found in patients with organic GHD. Seven cases of glucose intolerance (95/100,000 PY) and 22 cases of hypothyroidism (300/100,000 PY) were detected; about half of the cases (4 and 10 cases each) were considered to be related with rhGH treatment. Most of the growth-retarded patients showed continuous improvement in Ht SDS, with the most prominent effect observed within a year of treatment initiation. The beneficial effect of rhGH on Ht SDS gain was maintained for 2-4 years. CONCLUSIONS: The incidence of AEs of interest in rhGH-treated patients was low, and most of the neoplasms were benign and/or non-related to rhGH. Most patients benefited from the therapy in terms of height increment.
Source: PLoS ONE
Institutions: Korea University, Korea University Ansan Hospital, Dong-A University, Asan Medical Center, University of Ulsan, Yonsei University, Seoul National University, Seoul National University Bundang Hospital, Konkuk University, Konkuk University Medical Center, Hallym University, LG Chem (South Korea)
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,595
Funders: Chonbuk National University, Chonnam National University, Chosun University, Chungbuk National University, Chungnam National University, Kangwon National University, Keimyung University, Konyang University, Kyungpook National University, Soonchunhyang University, Ewha Womans University, Hallym University, Sungkyunkwan University, Catholic University of Korea, Catholic Kwandong University, CHA University, LG Chem, Samsung, Seoul St. Mary's Hospital, Catholic University of Korea
OpenAlex ID: W2946348977