Year: 2019
Type: editorial
Abstract: Immune system-tissue interactions mediate the success or failure of many clinical treatments.Recently, studies regulating these interactions have shown a dramatic impact on the study of immunity in health and disease and point to the development of therapeutic intervention in the fields of cellular therapy, regenerative, and precision medicine."Immunoengineering" is an emerging, interdisciplinary research subject that applies immunological principles and engineering tools with methods from molecular, cellular, and biomaterials-based approaches for precisely measuring, modeling and modulating immune responses.Applications include eradicating immune diseases and cancer, improving regenerative medicine and wound-healing responses, circumventing immunerejection of engineered tissue, and attenuating autoimmune and immunosuppressive disorders.However, realizing this potential requires precise control over the interface between immune function and tissue homeostasis.New understanding of immune-tissue interactions highlights the great potential of modulating immune-tissue bio-interfaces through engineered biomaterials to precisely and selectively regulate immune functions.With innovative engineering techniques and insights into how the immune system interacts with bio-interfaces, more effective therapeutic and diagnostic strategies can be developed.This special issue on "Bio-Interfaces for Immunoengineering" focuses specifically on emergent research in the fields of cell/molecular immunobiology, biomaterials, microfluidics-based diagnostics and disease modeling, tissue engineering, and mechanobiology.By fostering interactions among renowned and respected experts in these research fields, we hope to bridge the gap between basic science and clinical research to translate immune-based innovations towards the future clinical development of novel immunoengineering strategies.Knowledge regarding the interactions between immune cells and their microenvironment is critical for developing functional biomaterials and bio-interfaces for precisely and selectively regulating immune responses.Liu et al. (see article 201801578) reviewed the extracellular-matrix (ECM) based strategies for designing biomaterials for modulating immune functions.Specifically, Shin et al. discussed the regulation of bone
Source: Advanced Healthcare Materials
Authors: Weiqiang Chen, Deok‐Ho Kim
Institutions: New York University, University of Washington
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2946443874