Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
Year: 2019
Type: review
Abstract: The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,350
Funders: European Molecular Biology Organization, New York State Department of Health, Helsingin Yliopisto, New York State Stem Cell Science, European Commission, Deutsche Forschungsgemeinschaft, Academy of Finland, Max-Planck-Gesellschaft, National Institutes of Health, European Research Council, National Institute on Deafness and Other Communication Disorders, National Institute of Arthritis and Musculoskeletal and Skin Diseases
OpenAlex ID: W2946458164