EP-1574 Four-year outcomes of hypofractionated proton therapy for localized prostate cancer
Year: 2019
Type: conference-abstract
Abstract: Purpose or ObjectivePrediction of genitourinary (GU) and gastrointestinal (GI) toxicity after prostate cancer intensity modulated radiotherapy (IMRT) based on organs at risk (OAR) prescriptions is limited.Therefore, we investigated the potential impact of bladder-, rectal-and target volumes on acute side-effects of patients treated in a prospective study. Material and MethodsTwenty-eight patients received a dose-escalated IMRT of localized prostate cancer (257/2007B01).Radiotherapy was performed using the coverage probability concept to a total dose of 78Gy in 39 fractions.All patients underwent at least three planning CTs and were instructed according to a bladder-rectal filling protocol (aim: bladder volume of 250-500ml, empty rectum).Contouring of OARs and target volumes was performed in each CT and three OARvolumes per patient were measured.Incidence of acute GU/GI-toxicities (RTOG) was correlated with bladder-, rectal-and PTV-volumes.The volumes of 28 patients were descriptively evaluated by SPSS and subdivided in 4 quartiles (i.e. 7 patients per quartile). ResultsAcute toxicity was predominately detected in patients with small bladder volume, large or small rectal volume and large target volume.
Source: Radiotherapy and Oncology
Authors: A. GrewaL, C. Schonewold, S. Both, S. Lam, S. Mazzoni, J. Bekelman, J. Christodouleas, N. Vapiwala
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,000
OpenAlex ID: W2946477741