The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis
Year: 2019
Type: article
Abstract: BACKGROUND: Autonomic nervous system effects have been hypothesized as a mechanism of air pollutant health effects, though scant prior epidemiologic research has examined the association between air pollutants and catecholamines. OBJECTIVES: To examine the association of long-term air pollutants with three urinary catecholamines: dopamine (DA), epinephrine (EPI), and norepinephrine (NE). As a secondary aim, we also examined the association between short-term (or acute) exposure to fine particulate matter [particulate matter with aerodynamic diameter [Formula: see text] ([Formula: see text])] and those catecholamines. METHODS: We used data from the Multi-Ethnic Study of Atherosclerosis (MESA) and two of its ancillary studies, the MESA Air Pollution Study and the MESA Stress Study, to provide exposure and outcome data. DA, EPI, and NE from urine samples were collected from 2004 to 2006 from 1,002 participants in the New York, New York, and Los Angeles, California, study sites. Spatiotemporal models incorporated cohort-specific monitoring and estimated annual average pollutant concentrations ([Formula: see text], [Formula: see text], [Formula: see text] and black carbon) at participants' homes the year prior to urine collection. Secondarily, short-term [Formula: see text] was evaluated (day of, day prior, and 2- to 5-d lags prior to urine collection). Several covariates were considered confounders (age, race, sex, site, socioeconomic status, cardiovascular disease risk factors, psychosocial stressors, and medication use) in linear regression models. RESULTS: A [Formula: see text] higher annual [Formula: see text] concentration was associated with 6.3% higher mean EPI level [95% confidence interval (CI): 0.3%, 12.6%]. A 2-[Formula: see text] higher annual ambient [Formula: see text] concentration was associated with 9.1% higher mean EPI (95% CI: 3.2%, 15.3%) and 4.4% higher DA level (95% CI: 1%, 7.9%). [Formula: see text], black carbon, and short-term [Formula: see text] exposures were not significantly associated with any of the catecholamines. CONCLUSIONS: We found an association between EPI and long-term concentrations of [Formula: see text] and [Formula: see text] and an association between DA and long-term ambient [Formula: see text]. These novel findings provide modest support for the hypothesis that air pollutant exposures are related to sympathetic nervous system activation. https://doi.org/10.1289/EHP3286.
DOI: 10.1289/ehp3286
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: G109384441, G1261793039, MESA, G1276754516, G1294553593, G1409423729, G1640378483, G1686417863, Dimension reduction for spatially misaligned data, with application to air pollution epidemiology, G1802223128, Wake Forest Clinical and Translational Science Award, G1982334678, G1983464145, G1988283880, G2095596736, G2095942735, G2130630498, G2144938473, G22458031, G2262782284, MESA, Interaction of Air Pollution and Psychosocial Stress on Cardiovascular Disease., G2585438117, G2726417417, G2733059257, MESA, G2837638605, G286372155, G2905571579, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G2952093371, G3064274663, G3093995152, G33312777, G3482531243, G3568487487, G3595232572, G3647016462, G3687594596, MESA, G3990748671, G399481048, G4079570820, G4222455271, G4246339746, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4309390892, G4512137732, G4590187187, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G4986157935, G5075046117, G5088122703, G5108002584, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5234713383, G556483404, G562502316, G5653954166, G5654179670, G5787256936, Environmental Factors in Cardiovascular Disease, G6037063402, G6095866717, G6359107525, G6393075246, Institute for Clinical and Translational Research, MESA, G6514094751, G66341962, G6742279884, G6856766826, G7047602405, G7055397874, G7166352866, Stress, Gene-Environment Interaction and Cardiovascular Disease, G7333737664, MESA, G7399262704, G7455404317, Socioeconimic Patterning of Inflammation and Hemostasis, UCLA Older Americans Independence Center, G78770644, Clinical and Translational Science Award, G8145863542, G8823037953, G8852914737, G9000004549, G9000004784, G9000006353, G9000017360, G9000019818, G9000025517, G9000063950, G9000065698, G9000249658, G9000318776, University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment, G991334795
OpenAlex ID: W2946565470