Work

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape

Year: 2019

Type: review

Abstract: Most cancer deaths are due to metastasis, and almost all cancers have their preferential metastatic organs, known as "organotropism metastasis". Epithelial-mesenchymal plasticity has been described as heterogeneous and dynamic cellular differentiation states, supported by emerging experimental evidence from both molecular and morphological levels. Many molecular factors regulating epithelial-mesenchymal plasticity have tissue-specific and non-redundant properties. Reciprocally, cellular epithelial-mesenchymal plasticity contributes to shaping organ-specific pre-metastatic niche (PMN) including distinct local immune landscapes, mainly through secreted bioactive molecular factors. Here, we summarize recent progress on the involvement of tumor epithelial-mesenchymal plasticity in driving organotropic metastasis and regulating the function of different immune cells in organ-specific metastasis.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm8050747

Authors: Xiang Nan, Jiang Wang, Haowen Nikola Liu, Stephen T.C. Wong, Hong Zhao

Institutions: University of Science and Technology of China, Houston Methodist, Weill Cornell Medicine, Tongji Hospital

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,824