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LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma.

Year: 2017

Type: article

Abstract: Ewing sarcoma is a predominantly paediatric cancer with a high rate of metastasis and reoccurrence. A new surface marker called LINGO-1 was recently identified on Ewing tumours as a potential target for antibody-mediated therapies. However, such targeting requires caution because of LINGO-1 expression on some brain cells. Although the blood-brain-barrier exists, small amounts of antibody may cross this barrier and cause harmful side-effects. In this perspective, we suggest some options to alleviate this risk that can make targeting tumour cells expressing the LINGO-1 antigen a safe option.

Source: PubMed

Authors: Arvind Jain, Jing Zhang, Terence Rabbitts

Institutions: University of Oxford, MRC Weatherall Institute of Molecular Medicine

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2946714386

FWCI: 0.131

Cites: 22

Cited by: 1

Related to: 10