Work

Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia

Year: 2019

Type: article

Study design: Observational Study

Abstract: pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3-56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofz263

Authors: Ella M Meumann, Nicholas M Anstey, Bart J Currie, Kim A Piera, Robert Baird, Derek S Sarovich, Joshua S Davis

Institutions: Menzies School of Health Research, Royal Darwin Hospital, University of the Sunshine Coast, John Hunter Hospital, University of Newcastle Australia

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053

Funders: Menzies School of Health Research, Medical Research Council, National Health and Medical Research Council, Advance Queensland

Awards: Pathophysiology and treatment of malaria in our region, G3695483245, G4209832124, Molecular epidemiology of Mycobacterium tuberculosis infection in the Northern Territory, Australia, G7305616931, Strengthening the evidence base for the management of common severe infectious diseases

OpenAlex ID: W2946887546

FWCI: 0.173

Cites: 14

Cited by: 3

Related to: 10