Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies
Year: 2019
Type: article
Abstract: INTRODUCTION: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. METHODS: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques. RESULTS: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. DISCUSSION: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
Authors: Daniela Perani, Daniela Perani, Leonardo Iaccarino, Andreas H. Jacobs, IMBI Brain Imaging Working Group, Adriaan A. Lammertsma, Agneta Nordberg, Albert D. Windhorst, Alexander Gerhard, Alexandra Winkeler, Andreas H. Jacobs, Anthony Gee, Bertrand Kuhnast, Christer Halldin, Daniela Perani, Daniela Perani, David Brooks, Elena Rodriguez‐Vieitez, Federico E. Turkheimer, Francisco López‐Picón, Gitte M. Knudsen, Johnny Vercouillie, Juha O. Rinne, Karl Herholz, Koen Van Laere, Andrea Varrone, Marie Joao Santiago‐Ribeiro, Matthias M. Herth, Michael A. Carroll, Sylvie Chalon, Michel Bottlaender, Oskar Hansson, Paul Edison, Rainer Hinz, Ronald Boellaard, Rosa Maria Moresco, Sabina Pappata
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,000
Funders: Aarhus Universitet, Università degli Studi di Milano, EU Joint Programme – Neurodegenerative Disease Research, Imperial College London, King's College London, University of Manchester, Institut National de la Santé et de la Recherche Médicale, Vrije Universiteit Amsterdam, Lunds Universitet, Ministero dell’Istruzione, dell’Università e della Ricerca, Karolinska Institutet, Universitair Medisch Centrum Groningen, Rigshospitalet, Region Hovedstaden, Turun Yliopisto, Varsinais-Suomen Sairaanhoitopiiri, Turun Yliopistollinen Keskussairaala
OpenAlex ID: W2946946490