Work

A Poly (Lactic Co Glycolic) Acid Based Dry Powder Inhaler for the Treatment of Pulmonary Tuberculosis

Year: 2017

Type: dissertation

Abstract: The goal of this paper was to investigate the feasibility of a novel Poly (Lactic Co Glycolic) Acid (PLGA) based Dry Powder Inhaler in the treatment of pulmonary tuberculosis. First line TB drugs are highly effective in treating TB, but the lengthy treatment course and side effects associated with their use impacts negatively on treatment compliance. The advantages of using a Dry Powder Inhaler containing a fixed dose combination of first line antitubercular drugs in a PLGA carrier are investigated. Issues relating to the adequacy of current World Health Organization dosing recommendations are discussed and a set of clinical trials is proposed to assess the safety and efficacy of the Dry Powder Inhaler.

Source: Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Author: Marc Bartolucci

Language: English

Topic: Inhalation and Respiratory Drug Delivery

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2947096430

Cites: 51

Cited by: 1

Related to: 10