Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults
Year: 2019
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To assess cross-sectional associations of neurofibrillary tangles, measured by tau-PET, with cognitive performance in cognitively unimpaired (CU) adults. METHODS: Tau- and amyloid-PET were performed in 579 CU participants aged 50-98 from the population-based Mayo Clinic Study of Aging. Associations between tau-PET signal in 43 brain regions and cognitive test scores were assessed using penalized linear regression. In additional models, participants were classified by normal/abnormal global amyloid-PET (A+/A-) and normal/abnormal regional tau-PET (T+/T-). Regional tau-PET cutpoints were defined as standardized uptake value ratio (SUVR) greater than the 95th percentile of tau-PET SUVR in that region among 117 CU participants aged 30-49. RESULTS: scores was seen in the entorhinal cortex; this association was independent of tau-PET signal in other brain regions. Tau-PET in the entorhinal cortex was also associated with poorer global and language performance. In the entorhinal cortex, T+ was associated with lower memory performance among both A- and A+. CONCLUSIONS: Tau deposition in MTL regions, as reflected by tau-PET signal, was associated with poorer performance on memory tests in CU participants. The association with entorhinal cortex tau-PET was independent of tau-PET signal in other brain regions. Longitudinal studies are needed to understand the fate of CU participants with elevated medial temporal tau-PET signal.
Source: Neurology
Authors: Val J. Lowe, Tyler J. Bruinsma, Heather J. Wiste, Hoon-Ki Min, Stephen D. Weigand, Ping Fang, Matthew L. Senjem, Terry M. Therneau, Bradley F. Boeve, Keith A. Josephs, Mukesh K. Pandey, Melissa E. Murray, Kejal Kantarci, David T. Jones, Prashanthi Vemuri, Jonathan Graff-Radford, Christopher G. Schwarz, Mary M. Machulda, Michelle M. Mielke, Rosebud O. Roberts, David S. Knopman, Ronald C. Petersen, Clifford R. Jack
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Mayo Clinic, Pfizer, Biogen, Mayo Foundation for Medical Education and Research, National Institutes of Health, Genentech, Avid Radiopharmaceuticals, National Institute on Aging, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke
Awards: G2212362641, PIB PET Scanning in Speech and Language Based Dementias, Manipulating tau's posttranslational modifications to block disease progression in vivo, G3485349950, Alzheimers Disease Patient Registry, G413369726, G4583749874, Evaluating and Extending Our Hypothetical Model of Alzheimer's Biomarkers, G5795572654, Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy Syndromes, Prevention of Alzheimer's disease in women: risks and benefits of hormone therapy, Development, Validation, and Application of an Imaging based CVD Scale, Brain Aging and Alzheimer's Biomarker Classification Using Amyloid PET, tau PET, and Neurodegeneration on MRI: Developing the ATN system, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W2947200125