14-3-3 proteins: an important regulator of autophagy in diseases.
Year: 2017
Type: article
Abstract: Autophagy is a cell digestion process that determines cell fate by promoting cell survival or inducing cell death in a cell context-dependent manner. Several classical signaling pathways, such as phosphoinositide-3-kinase and mammalian target of rapamycin, tightly regulate autophagy. 14-3-3 proteins regulate various signaling pathways by phosphorylation-dependent binding with partner proteins. 14-3-3 proteins also regulate autophagy by binding with autophagy-related proteins such as Beclin-1 and hVPS34. This review summarizes the role of 14-3-3 proteins in the control of autophagy in cancer, neurodegenerative diseases and other pathological conditions.
Source: Europe PMC (PubMed Central)
Institutions: Jiangsu University, Wuxi People's Hospital
Language: English
Topic: 14-3-3 protein interactions
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2947246222