CRTAM Shapes the Gut Microbiota and Enhances the Severity of Infection
Year: 2019
Type: article
Abstract: Gut lymphocytes and the microbiota establish a reciprocal relationship that impacts the host immune response. Class I–restricted T cell–associated molecule (CRTAM) is a cell adhesion molecule expressed by intraepithelial T cells and is required for their retention in the gut. In this study, we show that CRTAM expression affects gut microbiota composition under homeostatic conditions. Moreover, Crtam−/− mice infected with the intestinal pathogen Salmonella exhibit reduced Th17 responses, lower levels of inflammation, and reduced Salmonella burden, which is accompanied by expansion of other microbial taxa. Thus, CRTAM enhances susceptibility to Salmonella, likely by promoting the inflammatory response that promotes the pathogen’s growth. We also found that the gut microbiota from wild-type mice, but not from Crtam−/− mice, induces CRTAM expression and Th17 responses in ex–germ-free mice during Salmonella infection. Our study demonstrates a reciprocal relationship between CRTAM expression and the gut microbiota, which ultimately impacts the host response to enteric pathogens.
Source: The Journal of Immunology
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Siderophore-based antibiotics: consequences for the microbiota and bacterial pathogens, Development of siderophore-based vaccines against non-typhoidal Salmonella infection, Harnessing iron acquisition to hinder enterobacterial pathogenesis, The new chemokine CCL28 and its role during Salmonella infection, Nutritional immunity during Salmonella infection, Nutritional immunity during Salmonella infection
OpenAlex ID: W2947280445