Work

NF-κB RelA Is Required for Hepatoprotection during Pneumonia and Sepsis

Year: 2019

Type: article

Abstract: ) mice during pneumonia. The absence of RelA resulted in hepatotoxicity across several models of pneumonia, sepsis, and NKT cell activation. Injury was associated with increased levels of activated caspase-3 and -8 and substantial alteration of the hepatic transcriptome. Hepatotoxicity in the absence of RelA could be reversed by neutralization of tumor necrosis factor alpha (TNF-α). These results indicate the requirement of RelA-dependent inducible hepatoprotection during pneumonia and sepsis. Further, the results demonstrate that RelA-dependent gene programs are critical for maintaining liver homeostasis against TNF-α-driven immunotoxicity.

Source: Infection and Immunity

DOI: 10.1128/iai.00132-19

Authors: Yuri Kim, Eri Allen, Lillia A. Baird, Elise M. Symer, Filiz T. Korkmaz, Elim Na, Christine V. Odom, Matthew R. Jones, Joseph P. Mizgerd, Katrina E. Traber, Lee J. Quinton

Institution: Boston University

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G2214953841, G3644982317, G3925963339, G477853788, G5349148586, Lung-resident antibacterial heterotypic immunity, Pneumonia Biology, G6791881364, G7496931201, G8153961006, G9000096298, G9000097463, G9000136237, Biology of the Lung: A Multidisciplinary Program

OpenAlex ID: W2947313191

FWCI: 0.415

Cites: 59

Cited by: 13

Related to: 10