Work

mRNA methylation in cell senescence

Year: 2019

Type: review

Abstract: Cellular senescence, a developmental program central to normal aging and aging pathologies, is robustly regulated at the post‐transcriptional level. This regulation involves the interaction of RNA‐binding proteins and noncoding RNAs with senescence‐associated messenger RNAs (mRNAs). There is increasing evidence that these associations are modulated by chemical modifications of specific mRNA nucleotides which can enhance or reduce the binding of regulatory factors. Recent technological advances in mass spectrometry, next‐generation sequencing, and genome mapping have improved markedly the detection of mRNA modifications. Given the rising interest in the epitranscriptomic control of gene expression in aging, we discuss our incipient understanding of the chemical mRNA modifications, specifically m6A and m5C, that influence cellular senescence. This article is categorized under: RNA Export and Localization > RNA Localization RNA Processing > RNA Editing and Modification

Source: Wiley Interdisciplinary Reviews - RNA

DOI: 10.1002/wrna.1547

Authors: Gabriel Casella, Dimitrios Tsitsipatis, Kotb Abdelmohsen, Myriam Gorospe

Institutions: National Institutes of Health, National Institute on Aging

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging