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Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

Year: 2019

Type: article

Study design: Observational Study

Abstract: In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciz430

Authors: Kevin L Steiner, Mamun Kabir, Jeffrey W Priest, Biplob Hossain, Carol A Gilchrist, Heather Cook, Jennie Z Ma, Poonum S Korpe, Tahmeed Ahmed, A S G Faruque, Rashidul Haque, William A Petri

Institutions: University of Virginia, International Centre for Diarrhoeal Disease Research, Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Johns Hopkins University

Language: English

Topic: Parasitic Infections and Diagnostics

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,334

Funders: Bill and Melinda Gates Foundation, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: G1149900786, G4534893475, G454693185, G6061822148, International Centre for Diarrhoeal Disease Research, Bangladesh - to measure the acute and long-term health burden from cryptosporidiosis on infants in rural and urban Bangladesh through innovative diagnostic appr..., G9000090596, G9000172646, Infectious Diseases Training Program

OpenAlex ID: W2947727240

FWCI: 0.956

Cites: 15

Cited by: 15

Related to: 10