Work

Synthetic Utility of One-Pot Chemoenzymatic Reaction Sequences

Year: 2019

Type: article

Abstract: In recent years, there has been a rapid and sustained increase in the development and use of one-pot chemoenzymatic reaction processes for the efficient synthesis of high-value molecules. This strategy can provide a number of advantages over traditional synthetic methods, including high levels of selectivity in reactions, mild and sustainable reaction conditions, and the ability to rapidly build molecular complexity in a single reaction vessel. Here, we present several examples of chemoenzymatic one-pot reaction sequences that demonstrate the diversity of transformations that can be incorporated in these processes.

Source: Synlett

DOI: 10.1055/s-0037-1611848

Authors: Tyler J. Doyon, Alison R. H. Narayan

Institution: University of Michigan

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, National Institute of General Medical Sciences

Awards: G859883141, Expanding the synthetic utility of enzymes