Organoids by design
Year: 2019
Type: article
Abstract: Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in organized assembly and acquisition of tissue function. These efforts have relied on studies of organ assembly during embryonic development and have resulted in the development of organoids with multilayer tissue complexity and higher-order functions. We discuss how the next generation of organoids can be designed by means of an engineering-based narrative design to control patterning, assembly, morphogenesis, growth, and function.
Source: Science
Authors: Takanori Takebe, James M. Wells
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Funders: New York Stem Cell Foundation, Takeda Science Foundation, National Institutes of Health, Japan Society for the Promotion of Science, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G166906552, Modeling monogenic steatohepatitis using human liver organoids, G3452857965, G4558700982, G6373447378, Inter-cellular RNA transfer-driven reprogramming, G9000062855, G9000075468, G9000316135, CLEAR Consortium: Discovering the Developmental Mechanisms of Trachea-Esophageal Birth Defects
OpenAlex ID: W2948307638