Work

P599Relationship between coronary artery calcium and hyperaemic myocardial blood flow in asymptomatic adults with type 2 diabetes

Year: 2019

Type: article

Abstract: Funding Acknowledgements: This study is funded by a British Heart Foundation Clinical Research Training Fellowship (BHF CRTF 32190, Dr GS Gulsin). Background: The relationship between coronary artery calcium score (CAC) and hyperaemic myocardial blood flow (MBF) in asymptomatic people with type 2 diabetes (T2D) and no history of cardiovascular disease is unknown. Purpose: To determine whether CAC is independently associated with stress MBF in asymptomatic people with T2D. Methods: We recruited adults with T2D and no history of cardiovascular disease. Subjects underwent anthropometry, CT CAC and adenosine stress 3T CMR. Perfusion imaging used a dual sequence and inline automated reconstruction and post-processing for quantification. Subjects with reversible perfusion defects on visual analyses of perfusion images were excluded. Results: 29 people with T2D were included. Anthropometric, CAC and CMR data are presented in Table 1. CAC was the only univariable predictor of hyperaemic global MBF, with which it showed an inverse correlation (Table 1). In a multivariable model containing age, gender and CAC, CAC was the only independent predictor of global MBF (β=-0.409, p = 0.032). Conclusions: In asymptomatic people with T2D and no perfusion defects, CAC is an independent determinant of stress MBF. Non-obstructive coronary disease should therefore be accounted for when assessing potential causes of microvascular dysfunction. Table 1. Baseline anthropometric, CAC and CMR data, with univariate predictors of global stress MBF.

Source: European Heart Journal - Cardiovascular Imaging

DOI: 10.1093/ehjci/jez116.005