Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium
Year: 2019
Type: article
Abstract: The attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factors. To date, much of the research on environmental determinants of disease has focused on single exposures generally measured at a single time point. In order to address this limitation, the concept of the exposome has been introduced as a comprehensive approach, studying the full complement of environmental exposures from conception onwards. However, exposures are vast, dynamic, and diverse, and only a small proportion can be reasonably measured due to limitations in technology and feasibility. In addition, the interplay between genes and exposure as well as between different exposures is complicated and multifaceted, which leads to difficulties in linking disease or health outcomes with exposures. The large numbers of collected samples require well-designed logistics. Furthermore, the immense data sets generated from exposome studies require a significant computational investment for both data analysis and data storage. This report summarizes discussions during an international exposome symposium held at Gunma University in Japan regarding the concept of the exposome, challenges in exposome research, and future perspectives in the field.
Source: Metabolites
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,418
Funders: Foundation for the National Institutes of Health, Swedish Foundation for International Cooperation in Research and Higher Education, Hjärt-Lungfonden, Vetenskapsrådet, National Institutes of Health, European Research Council, Japan Society for the Promotion of Science, National Institute of Environmental Health Sciences, H2020 European Research Council
Awards: G1887494241, G1971487083, 小児の化学物質複合曝露メカニズムの解明と質量分析を用いた革新的基盤技術の開発, G2203876710, Integrative Metabolomics and Exposomics Study of Severe Asthma in Adults, G2547695748, Novel lipid mediators in the induction and resolution of chronic airway inflammation, Predicting asthma exacerbations through longitudinal metabolomics, Mapping the Plasma Exposome and its Association with Human Cardiovascular Disease, G4761915256, G4788494525, G5478970381, G6812615423, A TRranslational approach to Identify Biomarkers for Asthma and Lung function impairment, Reconstructing fetal toxicant exposure and homeostatic disruptions, G8310345707, G85211502, Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS), Center for Environmental Health in Northern Manhattan
OpenAlex ID: W2948930785