Year: 2019
Type: article
Abstract: Phenazine-1-carboxylic acid (PCA) as a natural product widely exists in microbial metabolites of Pseudomonads and Streptomycetes, which displays potent inhibitory activities against plant pathogens, and has medical antibacterial and antitumor effects, and so on.In this review, the biosynthesis and chemosynthesis of phenazine-1-carboxylic acid are summarized.At the same time, the diverse biological evaluations of its biosynthetic and chemosynthetic analogues are summarized, which could provide reference for the study of structural modifications and biological activities of these analogues.Keywords phenazine-1-carboxylic acid; analogues; research progress 吩嗪-1-羧酸(Phenazine-1-carboxylic acid, PCA)(图 1) 是一种重要的含氮杂环化合物, 广泛存在于许多微生物 的代谢物中, 如链霉菌 Streptomyces [ 1 ] 、假单胞菌 Pseudomonads [2] 等. 然而, 最早关于吩嗪-1-羧酸的报道 始于 20 世纪 30 年代, 是在化学染料的合成中被偶然发 现, 随后作为染料中间体或滤色试剂进行了研究 [3,4] .直 到 20 世纪 50 年代, 科学家从微生物 Streptomyces chromogenus sp 代谢物中分离得到吩嗪-1-羧酸, 发现其 具有抗结核菌、抑制海藻生长等活性 [5,6] 显示出良好的抗肿瘤活性 [7] .Thanabalasingam [8] 报道了 N N O OH Phenazine-1-carboxylic acid (PCA) 图 1 吩嗪-1-羧酸的化学结构 Figure 1 Chemical structure of phenazine-1-carboxylic acid 从一种植物内生真菌稻黑孢霉 Nigrospora oryzae 的次级 代谢物中分离, 得到了吩嗪-1-羧酸与吩嗪-1-甲酰胺, 对植物病原真菌芽枝状枝孢具有很好的抑制效果.关于吩嗪-1-羧酸及类似物的活性研究国内起步较 晚, 主要集中在农用杀菌剂领域.
Authors: Xiang Zhu, Qinglai Wu, Junkai Li
Institution: Yangtze University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G2682397169, G3774500672
OpenAlex ID: W2948977582